Different expression pattern of human cytomegalovirus-encoded microRNAs in circulation from virus latency to reactivation.

ABSTRACT:

Background

Human cytomegalovirus (HCMV) is a beta-hersvirinae that has a high latent infection rate worldwide and can cause serious consequences in immunocompromised patients when reactivation; however, the mechanism of how HCMV convert from latent to reactivation has rarely been investigated. In the present study, we aimed to perform a comprehensive analysis of the HCMV-encoded microRNA (miRNA) profile in serum of patients upon HCMV reactivation from latency and to further evaluate its clinical significance for the disease monitoring and preventing usefulness.

Methods

Serum samples from 59 viremia patients and 60 age-gender matched controls were enrolled in this study for screening and validation of different expression of HCMV miRNAs. Serum concentrations of 22 known HCMV

SUBMITTER: Zhou W 

PROVIDER: S-EPMC7727131 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature