Hepatic transcriptome and DNA methylation patterns following perinatal and chronic BPS exposure in male mice.

ABSTRACT:

Background

Bisphenol S (BPS) is a common bisphenol A (BPA) substitute, since BPA is virtually banned worldwide. However, BPS and BPA have both endocrine disrupting properties. Their effects appear mostly in adulthood following perinatal exposures. The objective of the present study was to investigate the impact of perinatal and chronic exposure to BPS at the low dose of 1.5 μg/kg body weight/day on the transcriptome and methylome of the liver in 23 weeks-old C57BL6/J male mice.

Results

This multi-omic study highlights a major impact of BPS on gene expression (374 significant deregulated genes) and Gene Set Enrichment Analysis show an enrichment focused on several biological pathways related to metabolic liver regulation. BPS exposure also induces a hypomethylation in 58.5% o

SUBMITTER: Brulport A 

PROVIDER: S-EPMC7727143 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature