A smart scaffold composed of three-dimensional printing and electrospinning techniques and its application in rat abdominal wall defects.

ABSTRACT:

Background

Biological composite scaffolds are increasingly being used in abdominal wall reconstruction but still have certain shortcomings. The present study describes here a novel three-dimensional (3D) scaffold fabricated by combining 3D printing (3DP) and electrospinning (ESP).

Methods

Biological composite scaffolds are composed of integrated 3DP interconnected macrofiber and random ESP microfiber networks. The 3DP scaffold retains intact 3D architecture and mechanical properties, while the ESP network serves as a cell entrapment system at the extracellular matrix (ECM) scale. Biological composite scaffolds are implanted in a defective rat abdominal wall to detect if it could induce early vascularization and reconstruction of the tissue defect.

Results

SEM analysis

SUBMITTER: Yang Z 

PROVIDER: S-EPMC7727174 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature