Two-weeks repeated-dose oral toxicity study of Pediococcus acidilactici J9 in a mice model.

ABSTRACT:

Background

Helicobacter pylori (H. pylori) is an important pathogen that causes chronic gastritis and peptic ulcer, and is related to the development of gastric carcinoma. Several chemicals, including antibiotics, have been used to eradicate H.pylori. However, more studies are yet requred to accomplish a sufficient therapy. Pediococcus acidilactici (P. acidilactici) J9 were studied for inhibition of binding of H.pylori binding to human gastric cell lines. This study was performed in order to investigate the repeated-dose toxicity of P. acidilactici J9 in male and female mice.

Results

C57BL/6 male and female Mus musculus were divided into four groups (n = 10 in each group). P. acidilactici J9 was administered daily by oral injection of vehicle control at dosage levels to a lo

SUBMITTER: Lee M 

PROVIDER: S-EPMC7727177 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature