IDPGK: characterization and identification of lysine phosphoglycerylation sites based on sequence-based features.

ABSTRACT:

Background

Protein phosphoglycerylation, the addition of a 1,3-bisphosphoglyceric acid (1,3-BPG) to a lysine residue of a protein and thus to form a 3-phosphoglyceryl-lysine, is a reversible and non-enzymatic post-translational modification (PTM) and plays a regulatory role in glucose metabolism and glycolytic process. As the number of experimentally verified phosphoglycerylated sites has increased significantly, statistical or machine learning methods are imperative for investigating the characteristics of phosphoglycerylation sites. Currently, research into phosphoglycerylation is very limited, and only a few resources are available for the computational identification of phosphoglycerylation sites.

Result

We present a bioinformatics investigation of phosphoglycerylation s

SUBMITTER: Huang KY 

PROVIDER: S-EPMC7727188 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature