Baseline Serum C-Reactive Protein Level Predicts Mortality in Cryptococcal Meningitis.

ABSTRACT:

Background

C-reactive protein (CRP) is an acute phase protein produced by the liver in response to systemic inflammation. CRP is a helpful surrogate biomarker used for following the progression and resolution of infection. We aimed to determine the association of baseline CRP level and the temporal change in CRP over time with cryptococcal meningitis outcome.

Methods

We reviewed 168 prospectively enrolled HIV-infected Ugandans with confirmed first-episode cryptococcal meningitis. Baseline plasma CRP collected within 5 days of meningitis diagnosis was categorized into quartiles. We compared baseline CRP with 18-week survival using time-to-event analysis.

Results

Of 168 participants, the baseline first quartile of serum CRP was <29.0 mg/L, second quartile 29.0-49.5 mg/L

SUBMITTER: Chesdachai S 

PROVIDER: S-EPMC7727340 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature