Suppressing Anterior Cingulate Cortex Modulates Default Mode Network and Behavior in Awake Rats.

ABSTRACT: The default mode network (DMN) is a principal brain network in the mammalian brain. Although the DMN in humans has been extensively studied with respect to network structure, function, and clinical implications, our knowledge of DMN in animals remains limited. In particular, the functional role of DMN nodes, and how DMN organization relates to DMN-relevant behavior are still elusive. Here we investigated the causal relationship of inactivating a pivotal node of DMN (i.e., dorsal anterior cingulate cortex [dACC]) on DMN function, network organization, and behavior by combining chemogenetics, resting-state functional magnetic resonance imaging (rsfMRI) and behavioral tests in awake rodents. We found that suppressing dACC activity profoundly changed the activity and connectivity of DMN, and t

SUBMITTER: Tu W 

PROVIDER: S-EPMC7727348 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature