Trials in developing a nanoscale material for extravascular contrast-enhanced ultrasound targeting hepatocellular carcinoma.

ABSTRACT:

Background

Medical imaging is an important approach for the diagnosis of hepatocellular carcinoma (HCC), a common life threaten disease, however, the diagnostic efficiency is still not optimal. Developing a novel method to improve diagnosis is necessary. The aim of this project was to formulate a material that can combine with GPC3 of HCC for targeted enhanced ultrasound.

Methods

A material of sulfur hexafluoride (SF₆) filled liposome microbubbles and conjugated with synthesized peptide (LSPMbs) was prepared and assessed in vitro and vivo. Liposome microbubbles were made of DPPC, DPPG, DSPE-PEG2000,and SF₆, using thin film method to form shell, followed filling SF₆, and conjugating peptide. A carbodiimide method was used for covalent conjugat

SUBMITTER: Wu S 

PROVIDER: S-EPMC7727372 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature