Association of diet with circulating trimethylamine-N-oxide concentration.

ABSTRACT:

Background

Trimethylamine-N-oxide (TMAO) is a compound that is present in seafood and produced through human gut microbial metabolism of its precursors. Previous studies have suggested that elevated TMAO concentrations are associated with an increased risk of cardiovascular events. However, the association between diet and TMAO concentrations in free-living adult populations has not been adequately described.

Objectives

The objective of this study was to identify dietary predictors of plasma TMAO concentrations.

Methods

TMAO concentrations were assessed in 2 fasting plasma samples collected 6 mo apart among 620 healthy men. Short-term and long-term dietary intakes were assessed during the same time-frame of blood collections via repeated 7-d dietary records (7DDRs) an

SUBMITTER: Hamaya R 

PROVIDER: S-EPMC7727477 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature