Magnetization Lifetimes Prediction and Measurements Using Long-Lived Spin States in Endogenous Molecules.

ABSTRACT: Nuclear magnetization storage in biologically-relevant molecules opens new possibilities for the investigation of metabolic pathways, provided the lifetimes of magnetization are sufficiently long. Dissolution-dynamic nuclear polarization-based spin-order enhancement, sustained by long-lived states can measure the ratios between concentrations of endogenous molecules on a cellular pathway. These ratios can be used as meters of enzyme function. Biological states featuring intracellular amino-acid concentrations that are depleted or replenished in the course of in-cell or in-vivo tests of drugs or radiation treatments can be revealed. Progressing from already-established long-lived states, we investigated related spin order in the case of amino acids and other metabolites featuring networks o

SUBMITTER: Teleanu F 

PROVIDER: S-EPMC7727668 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature