Dopamine release, diffusion and uptake: A computational model for synaptic and volume transmission.

ABSTRACT: Computational modeling of dopamine transmission is challenged by complex underlying mechanisms. Here we present a new computational model that (I) simultaneously regards release, diffusion and uptake of dopamine, (II) considers multiple terminal release events and (III) comprises both synaptic and volume transmission by incorporating the geometry of the synaptic cleft. We were able to validate our model in that it simulates concentration values comparable to physiological values observed in empirical studies. Further, although synaptic dopamine diffuses into extra-synaptic space, our model reflects a very localized signal occurring on the synaptic level, i.e. synaptic dopamine release is negligibly recognized by neighboring synapses. Moreover, increasing evidence suggests that cognitive pe

SUBMITTER: Wiencke K 

PROVIDER: S-EPMC7728201 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature