Long-term outcomes after gonadotropin-releasing hormone agonist treatment in boys with central precocious puberty.

ABSTRACT:

Objective

Gonadotropin-releasing hormone agonist (GnRHa) treatment improves the potential for gaining height in patients with central precocious puberty (CPP). However, most studies have focused on girls because CPP in boys is relatively rare. Therefore, we aimed to determine the effect of GnRHa treatment on auxological outcomes in boys with CPP.

Methods

Eighty-five boys with CPP were treated with leuprolide or triptorelin acetate 3.75 mg over 2 years. Anthropometry, bone age, sexual maturity rating, and predicted adult height (PAH) were assessed every 6 months. Furthermore, 20 boys were followed up after treatment discontinuation until achievement of the final adult height (FAH).

Results

The mean chronological age (CA) and bone age (BA) of the patients with CPP at tr

SUBMITTER: Shim YS 

PROVIDER: S-EPMC7728242 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature