Ontology highlight
ABSTRACT:
SUBMITTER: Houston R
PROVIDER: S-EPMC7728262 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
PLoS biology 20201130 11
The metabolite acetyl-coenzyme A (acetyl-CoA) serves as an essential element for a wide range of cellular functions including adenosine triphosphate (ATP) production, lipid synthesis, and protein acetylation. Intracellular acetyl-CoA concentrations are associated with nutrient availability, but the mechanisms by which a cell responds to fluctuations in acetyl-CoA levels remain elusive. Here, we generate a cell system to selectively manipulate the nucleo-cytoplasmic levels of acetyl-CoA using clu ...[more]