A multi-scale cortical wiring space links cellular architecture and functional dynamics in the human brain.

ABSTRACT: The vast net of fibres within and underneath the cortex is optimised to support the convergence of different levels of brain organisation. Here, we propose a novel coordinate system of the human cortex based on an advanced model of its connectivity. Our approach is inspired by seminal, but so far largely neglected models of cortico-cortical wiring established by postmortem anatomical studies and capitalises on cutting-edge in vivo neuroimaging and machine learning. The new model expands the currently prevailing diffusion magnetic resonance imaging (MRI) tractography approach by incorporation of additional features of cortical microstructure and cortico-cortical proximity. Studying several datasets and different parcellation schemes, we could show that our coordinate system robustly recapit

SUBMITTER: Paquola C 

PROVIDER: S-EPMC7728398 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature