Targeting Orphan Nuclear Receptors NR4As for Energy Homeostasis and Diabetes.

ABSTRACT: Orphan nuclear receptors are important members of the nuclear receptor family and may regulate cell proliferation, metabolism, differentiation, and apoptosis. NR4As, a subfamily of orphan nuclear receptors, have been reported to play key roles in carbohydrate and lipid metabolism and energy homeostasis. Popularity of obesity has resulted in a series of metabolic diseases such as diabetes and its complications. While imbalance of energy intake and expenditure is the main cause of obesity, the concrete mechanism of obesity has not been fully understood. It has been reported that NR4As have significant regulatory effects on energy homeostasis and diabetes and are expected to become new targets for discovering drugs for metabolic syndrome. A number of studies have demonstrated that abnormaliti

SUBMITTER: Zhang C 

PROVIDER: S-EPMC7728612 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature