Somatostatin expressing GABAergic interneurons in the medial entorhinal cortex preferentially inhibit layer_III-V pyramidal cells.

ABSTRACT: GABA released from heterogeneous types of interneurons acts in a complex spatio-temporal manner on postsynaptic targets in the networks. In addition to GABA, a large fraction of GABAergic cells also express neuromodulator peptides. Somatostatin (SOM) containing interneurons, in particular, have been recognized as key players in several brain circuits, however, the action of SOM and its downstream network effects remain largely unknown. Here, we used optogenetics, electrophysiologic, anatomical and behavioral experiments to reveal that the dendrite-targeting, SOM⁺ GABAergic interneurons demonstrate a unique layer-specific action in the medial entorhinal cortex (MEC) both in terms of GABAergic and SOM-related properties. We show that GABAergic and somatostatinergic neurotransmissi

SUBMITTER: Kecskes M 

PROVIDER: S-EPMC7728756 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature