Gut Microbiota and Metabolic Specificity in Ulcerative Colitis and Crohn's Disease.

ABSTRACT: Background: Inflammatory bowel disease (IBD) represents multifactorial chronic inflammatory conditions in the gastrointestinal tract and includes Crohn's disease (CD) and ulcerative colitis (UC). Despite similarities in pathobiology and disease symptoms, UC and CD represent distinct diseases and exhibit diverse therapeutic responses. While studies have now confirmed that IBD is associated with dramatic changes in the gut microbiota, specific changes in the gut microbiome and associated metabolic effects on the host due to CD and UC are less well-understood. Methods: To address this knowledge gap, we performed an extensive unbiased meta-analysis of the gut microbiome data from five different IBD patient cohorts from five different countries using QIIME2, DIAMOND, and STAMP bio

SUBMITTER: Sankarasubramanian J 

PROVIDER: S-EPMC7729129 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature