Gestational Diabetes Is Uniquely Associated With Altered Early Seeding of the Infant Gut Microbiota.

ABSTRACT: Gestational diabetes mellitus (GDM) is a worldwide public health problem affecting up to 27% of pregnancies with high predictive values for childhood obesity and inflammatory diseases. Compromised seeding of the infant gut microbiota is a risk factor for immunologic and metabolic diseases in the offspring; however, how GDM along with maternal obesity interact to alter colonization remains unknown. We hypothesized that GDM individually and in combination with maternal overweight/obesity would alter gut microbial composition, diversity, and short-chain fatty acid (SCFA) levels in neonates. We investigated 46 full-term neonates born to normal-weight or overweight/obese mothers with and without GDM, accounting for confounders including cesarean delivery, lack of breastfeeding, and exposure to

SUBMITTER: Soderborg TK 

PROVIDER: S-EPMC7729132 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature