PPARγ S273 Phosphorylation Modifies the Dynamics of Coregulator Proteins Recruitment.

ABSTRACT: The nuclear receptor PPARγ is essential to maintain whole-body glucose homeostasis and insulin sensitivity, acting as a master regulator of adipogenesis, lipid, and glucose metabolism. Its activation through natural or synthetic ligands induces the recruitment of coactivators, leading to transcription of target genes such as cytokines and hormones. More recently, post translational modifications, such as PPARγ phosphorylation at Ser273 by CDK5 in adipose tissue, have been linked to insulin resistance trough the dysregulation of expression of a specific subset of genes. Here, we investigate how this phosphorylation may disturb the interaction between PPARγ and some coregulator proteins as a new mechanism that may leads to insulin resistance. Through cellular and in vitro assays, we s

SUBMITTER: Dias MMG 

PROVIDER: S-EPMC7729135 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature