Transcriptome Reprogramming of CD11b⁺ Bone Marrow Cells by Pancreatic Cancer Extracellular Vesicles.

ABSTRACT: Pancreatic cancers (PC) are highly metastatic with poor prognosis, mainly due to delayed detection. We previously showed that PC-derived extracellular vesicles (EVs) act on macrophages residing in the liver, eliciting extracellular matrix remodeling in this organ and marked hepatic accumulation of CD11b⁺ bone marrow (BM) cells, which support PC liver metastasis. We here show that PC-EVs also bind to CD11b⁺ BM cells and induce the expansion of this cell population. Transcriptomic characterization of these cells shows that PC-EVs upregulate IgG and IgA genes, which have been linked to the presence of monocytes/macrophages in tumor microenvironments. We also report here the transcriptional downregulation of genes linked to monocyte/macrophage activation, trafficking, and

SUBMITTER: Maia J 

PROVIDER: S-EPMC7729189 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature