MIRRAGGE - Minimum Information Required for Reproducible AGGregation Experiments.

ABSTRACT: Reports on phase separation and amyloid formation for multiple proteins and aggregation-prone peptides are recurrently used to explore the molecular mechanisms associated with several human diseases. The information conveyed by these reports can be used directly in translational investigation, e.g., for the design of better drug screening strategies, or be compiled in databases for benchmarking novel aggregation-predicting algorithms. Given that minute protocol variations determine different outcomes of protein aggregation assays, there is a strong urge for standardized descriptions of the different types of aggregates and the detailed methods used in their production. In an attempt to address this need, we assembled the Minimum Information Required for Reproducible Aggregation Experiments

SUBMITTER: Martins PM 

PROVIDER: S-EPMC7729192 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature