Plasma Soluble CD146 as a Potential Diagnostic Marker of Acute Rejection in Kidney Transplantation.

ABSTRACT: Previous studies have implicated the role of CD146 and its soluble form (sCD146) in the pathogenesis of inflammatory diseases. However, the association between CD146 and acute rejection in kidney transplant patients remains unexplored. In this study, fifty-six patients with biopsy-proved rejection or non-rejection and 11 stable allograft function patients were retrospectively analyzed. Soluble CD146 in plasma was detected in peripheral blood by enzyme linked immunosorbent assay (ELISA), and local CD146 expression in graft biopsy was detected by immunohistochemistry. We found that plasma soluble CD146 in acute rejection recipients was significantly higher than in stable patients without rejection, and the biopsy CD146 staining in the rejection group was higher than that of the non-rejection

SUBMITTER: Liao J 

PROVIDER: S-EPMC7729194 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature