Performance of Glomerular Filtration Rate Estimating Equations Before and After Bariatric Surgery.

ABSTRACT:

Rationale & objective

Evaluation of glomerular filtration rate (GFR) is challenging in adults undergoing bariatric surgery because creatinine and cystatin C levels are influenced by changes in muscle and fat mass. Additionally, indexing of GFR by body surface area (BSA) may by affected by decreases in BSA.

Study design

Prospective observational study.

Setting & participants

27 adults with body mass index (BMI) ≥ 35 kg/m² who underwent measurement of GFR before and after bariatric surgery.

Outcomes

Indexed and nonindexed GFRs measured (mGFRs) using plasma iohexol clearance, indexed and nonindexed estimated GFR (eGFR) based on levels of creatinine, cystatin C, or both from Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations.

Analyt

SUBMITTER: Chang AR 

PROVIDER: S-EPMC7729215 | biostudies-literature | 2020 Nov-Dec

REPOSITORIES: biostudies-literature