TsrA Regulates Virulence and Intestinal Colonization in Vibrio cholerae.

ABSTRACT: Pathogenic strains of Vibrio cholerae require careful regulation of horizontally acquired virulence factors that are largely located on horizontally acquired genomic islands (HAIs). While TsrA, a Vibrionaceae-specific protein, is known to regulate the critical HAI virulence genes toxT and ctxA, its broader function throughout the genome is unknown. Here, we find that deletion of tsrA results in genomewide expression patterns that heavily correlate with those seen upon deletion of hns, a widely conserved bacterial protein that regulates V. cholerae virulence. This correlation is particularly strong for loci on HAIs, where all differentially expressed loci in the ΔtsrA mutant are also differentially expressed in the Δhns mutant.

SUBMITTER: DuPai CD 

PROVIDER: S-EPMC7729259 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature