A study on the pathogenesis of blood-heat psoriasis with transcriptome analysis.

ABSTRACT:

Background

Most existing studies on psoriasis' pathogenesis have focused on collecting epithelial cell gene sequences from psoriasis patients and normal subjects. In this paper, for the first time, high-throughput microarray was used to study the differential expression of genes in venous blood between patients with blood-heat psoriasis and normal subjects, providing theoretical support for studying the pathogenesis of blood-heat psoriasis.

Methods

Peripheral venous blood was collected from ten patients with blood-heat psoriasis and ten healthy volunteers for high-throughput microarray. The mRNAs, lncRNAs, and circRNAs related to blood-heat psoriasis were selected by analyzing the transcriptome microarray results. Then gene ontology (GO) analysis and KEGG signaling pathway a

SUBMITTER: Chen Z 

PROVIDER: S-EPMC7729302 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature