Target therapy for metastatic alveolar soft part sarcoma: a retrospective study with 47 cases.

ABSTRACT:

Background

Alveolar soft part sarcoma (ASPS) is a translocation-associated soft-tissue tumor resistant to conventional cytotoxic agents. This report aims to compare the efficacy of anlotinib versus pazopanib as targeted monotherapy in metastatic ASPS and to determine the impact of drug dosage reduction on disease control.

Methods

Sixteen and 31 patients with metastatic ASPS were respectively treated with anlotinib and pazopanib monotherapy at a single institution. Objective response rate (ORR), progression-free survival (PFS), and overall survival (OS) were retrieved and compared between both therapeutic arms. Adverse events (AEs) within each group were recorded. Kaplan-Meier survivorship curves computed the impact of drug dosage reduction on PFS.

Results

The anlotini

SUBMITTER: Liu J 

PROVIDER: S-EPMC7729354 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature