Hyperion imaging system reveals heterogeneous tumor microenvironment of oral squamous cell carcinoma patients at T1N0M0 stage.

ABSTRACT:

Background

Oral squamous cell carcinoma (OSCC) is a highly heterogeneous neoplasm where the identification of heterogeneity is a critical clinical need to improve treatment planning and prognosis prediction. Utilizing the Hyperion imaging system to carry out high-dimensional proteomics analysis on the heterogeneity of tumor samples, this study aims to detect and analyze the heterogeneity of OSCC without lymph node metastasis and explore potential contributing factors for poor prognosis of early-stage OSCC.

Methods

We collected tumor tissue samples from four OSCC patients at the T1N0M0 stage, who presented with similar clinical manifestations. Patient formalin-fixed, paraffin-embedded (FFPE) tissue sections were prepared and stained using a panel of 26 immune or tumor-related

SUBMITTER: Xie S 

PROVIDER: S-EPMC7729358 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature