Correlation between alterations of gut microbiota and miR-122-5p expression in patients with type 2 diabetes mellitus.

ABSTRACT:

Background

To investigate the correlation between gut microbiota and circulating microRNAs (miRNAs) in patients with primary diagnosis of type 2 diabetes mellitus (T2DM) and to explore the possible mechanisms of miRNA-gut microbiota crosstalke network in the regulation of the insulin signaling pathway and glucose homeostasis in T2DM.

Methods

T2DM patients and normal controls were recruited. Fasting plasma and fecal samples were collected from the subjects, and their biochemical indexes including fasting blood glucose (FBG), glycated hemoglobin (HbAlc), cholesterol (TC), total triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and insulin were recorded. The variations in intestinal microbiota in the two groups were analyzed using 16S rRNA third

SUBMITTER: Li L 

PROVIDER: S-EPMC7729379 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature