Nephrotoxicity of concomitant piperacillin/tazobactam and teicoplanin compared with monotherapy.

ABSTRACT:

Objectives

Piperacillin/tazobactam combined with vancomycin has been associated with a decline in renal function when compared with monotherapy. Teicoplanin is a glycopeptide similar to vancomycin. We investigated whether piperacillin/tazobactam combined with teicoplanin is associated with a decline in renal function as well.

Methods

We conducted a single-centre retrospective cohort study with data from our electronic health records from 9 August 2013 to 15 November 2019, including all adult patients that received either piperacillin/tazobactam, teicoplanin or piperacillin/tazobactam + teicoplanin. The incidence of acute kidney injury (AKI) at 48-72 h served as the primary outcome, whereas change in serum creatinine served as a secondary outcome.

Results

Of the 4202 i

SUBMITTER: Workum JD 

PROVIDER: S-EPMC7729383 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature