Transcriptional profiling of leukocytes in critically ill COVID19 patients: implications for interferon response and coagulation.

ABSTRACT:

Background

COVID19 is caused by the SARS-CoV-2 virus and has been associated with severe inflammation leading to organ dysfunction and mortality. Our aim was to profile the transcriptome in leukocytes from critically ill patients positive for COVID19 compared to those negative for COVID19 to better understand the COVID19-associated host response. For these studies, all patients admitted to our tertiary care intensive care unit (ICU) suspected of being infected with SARS-CoV-2, using standardized hospital screening methodologies, had blood samples collected at the time of admission to the ICU. Transcriptome profiling of leukocytes via ribonucleic acid sequencing (RNAseq) was then performed and differentially expressed genes as well as significantly enriched gene sets were identified

SUBMITTER: Gill SE 

PROVIDER: S-EPMC7729690 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature