Multi-Omics Integration Highlights the Role of Ubiquitination in CCl₄-Induced Liver Fibrosis.

ABSTRACT: Liver fibrosis is the excessive accumulation of extracellular matrix proteins that occurs in chronic liver disease. Ubiquitination is a post-translational modification that is crucial for a plethora of physiological processes. Even though the ubiquitin system has been implicated in several human diseases, the role of ubiquitination in liver fibrosis remains poorly understood. Here, multi-omics approaches were used to address this. Untargeted metabolomics showed that carbon tetrachloride (CCl₄)-induced liver fibrosis promotes changes in the hepatic metabolome, specifically in glycerophospholipids and sphingolipids. Gene ontology analysis of public deposited gene array-based data and validation in our mouse model showed that the biological process "protein polyubiquitination" is e

SUBMITTER: Mercado-Gomez M 

PROVIDER: S-EPMC7729774 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature