Linker-Regulated H₂S Release from Aromatic Peptide Amphiphile Hydrogels.

ABSTRACT: Controlled release is an essential requirement for delivery of hydrogen sulfide (H₂S) because of its reactive nature, short half-life in biological fluids, and toxicity at high concentrations. In this context, H₂S delivery via hydrogels may be beneficial as they can deliver H₂S locally at the site of interest. Herein, we employed hydrogels based on aromatic peptide amphiphiles (APAs) with tunable mechanical properties to modulate the rates of H₂S release. The APAs contained an aromatic S-aroylthiooxime (SATO) H₂S donor attached with a linker to a short IAVEEE hexapeptide. Linker units included carbonyl, substituted O-methylenes, alkenyl, and alkyl segments with the goal of evaluating the role of linker structure on self-a

SUBMITTER: Kaur K 

PROVIDER: S-EPMC7730058 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature