Synthesis of a Heterotelechelic Helical Poly(methacrylamide) and its Incorporation into a Supramolecular Triblock Copolymer.

ABSTRACT: We report the first heterotelechelic helical poly(methacrylamide) (PMAc) bearing orthogonal supramolecular binding sites on its chain-ends synthesized through a combination of reversible addition-fragmentation chain-transfer (RAFT) polymerization and thiol-bromo "click" chemistry. The heterotelechelic PMAc was assembled with two monotelechelic polymers featuring different secondary structures, namely a coil-like poly(styrene) and a helical poly(isocyanide), resulting in the formation of a coil-helix-helix supramolecular triblock copolymer through orthogonal metal coordination and hydrogen bonding interactions. Triblock assembly was confirmed through ¹H NMR spectroscopy, isothermal titration calorimetry (ITC) and viscometry. The individual polymer blocks retained their secondary

SUBMITTER: Deng R 

PROVIDER: S-EPMC7730060 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature