Microfluidic Tumor-on-a-Chip Model to Study Tumor Metabolic Vulnerability.

ABSTRACT: Tumor-specific metabolic adaptations offer an interesting therapeutic opportunity to selectively destroy cancer cells. However, solid tumors also present gradients of nutrients and waste products across the tumor mass, forcing tumor cells to adapt their metabolism depending on nutrient availability in the surrounding microenvironment. Thus, solid tumors display a heterogenous metabolic phenotype across the tumor mass, which complicates the design of effective therapies that target all the tumor populations present. In this work, we used a microfluidic device to study tumor metabolic vulnerability to several metabolic inhibitors. The microdevice included a central chamber to culture tumor cells in a three-dimensional (3D) matrix, and a lumen in one of the chamber flanks. This design created

SUBMITTER: Ayuso JM 

PROVIDER: S-EPMC7730115 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature