Characterization of Structural and Energetic Differences between Conformations of the SARS-CoV-2 Spike Protein.

ABSTRACT: The novel coronavirus disease 2019 (COVID-19) pandemic has disrupted modern societies and their economies. The resurgence in COVID-19 cases as part of the second wave is observed across Europe and the Americas. The scientific response has enabled a complete structural characterization of the Severe Acute Respiratory Syndrome-novel Coronavirus 2 (SARS-CoV-2). Among the most relevant proteins required by the novel coronavirus to facilitate the cell entry mechanism is the spike protein. This protein possesses a receptor-binding domain (RBD) that binds the cellular angiotensin-converting enzyme 2 (ACE2) and then triggers the fusion of viral and host cell membranes. In this regard, a comprehensive characterization of the structural stability of the spike protein is a crucial step to find new th

SUBMITTER: Moreira RA 

PROVIDER: S-EPMC7730245 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature