Interoceptive insular cortex participates in sensory processing of gastrointestinal malaise and associated behaviors.

ABSTRACT: The insular cortex plays a central role in the perception and regulation of bodily needs and emotions. Its modular arrangement, corresponding with different sensory modalities, denotes a complex organization, and reveals it to be a hub that is able to coordinate autonomic and behavioral responses to many types of stimuli. Yet, little is known about the dynamics of its electrical activity at the neuronal level. We recorded single neurons in behaving rats from the posterior insula cortex (pIC), a subdivision considered as a primary interoceptive cortex, during gastrointestinal (GI) malaise, a state akin to the emotion of disgust in humans. We found that a large proportion of pIC neurons were modulated during the rodent compensatory behaviors of lying on belly (LOB) and Pica. Furthermore, we

SUBMITTER: Aguilar-Rivera M 

PROVIDER: S-EPMC7730439 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature