Urinary Metabolomic Profiling in Streptozotocin-Induced Diabetic Mice after Treatment with Losartan.

ABSTRACT: Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage kidney disease. Renin-angiotensin system inhibitors such as losartan are the predominant therapeutic options in clinical practice to treat DKD. Therefore, it is necessary to identify DKD-related metabolic profiles that are affected by losartan. To investigate the change in metabolism associated with the development of DKD, we performed global and targeted metabolic profiling using 800 MHz nuclear magnetic resonance spectroscopy of urine samples from streptozotocin-induced diabetic mice (DM) with or without losartan administration. A principal component analysis plot showed that the metabolic pattern in the losartan-treated diabetic mice returned from that in the DM group toward that in the control mi

SUBMITTER: Hyeon JS 

PROVIDER: S-EPMC7730544 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature