Cancer Stem Cell-Associated Pathways in the Metabolic Reprogramming of Breast Cancer.

ABSTRACT: Metabolic reprogramming of cancer is now considered a hallmark of many malignant tumors, including breast cancer, which remains the most commonly diagnosed cancer in women all over the world. One of the main challenges for the effective treatment of breast cancer emanates from the existence of a subpopulation of tumor-initiating cells, known as cancer stem cells (CSCs). Over the years, several pathways involved in the regulation of CSCs have been identified and characterized. Recent research has also shown that CSCs are capable of adopting a metabolic flexibility to survive under various stressors, contributing to chemo-resistance, metastasis, and disease relapse. This review summarizes the links between the metabolic adaptations of breast cancer cells and CSC-associated pathways. Identifi

SUBMITTER: El-Sahli S 

PROVIDER: S-EPMC7730588 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature