Eosinophil microRNAs Play a Regulatory Role in Allergic Diseases Included in the Atopic March.

ABSTRACT: (1) Background: The atopic march is defined by the increased prevalence of allergic diseases after atopic dermatitis onset. In fact, atopic dermatitis is believed to play an important role in allergen sensitization via the damaged skin barrier, leading to allergic diseases such as allergic asthma and allergic rhinitis. The eosinophil, a pro-inflammatory cell that contributes to epithelial damage, is one of the various cells recruited in the inflammatory reactions characterizing these diseases. Few studies were conducted on the transcriptome of this cell type and even less on their specific microRNA (miRNA) profile, which could modulate pathogenesis of allergic diseases and clinical manifestations post-transcriptionally. Actually, their implication in allergic diseases is not fully understo

SUBMITTER: Belanger E 

PROVIDER: S-EPMC7730597 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature