PD-L1 expression in liver metastasis: its clinical significance and discordance with primary tumor in colorectal cancer.

ABSTRACT:

Background

The outcomes of immune checkpoint inhibitors in cancer patients with liver metastases are poor, which may be related to a different tumor microenvironment in liver metastases from primary tumors. This study was aimed to analyze PD-L1 expression and the immune microenvironment status in liver metastases and compare the differences of PD-L1 expression between primary tumors and liver metastases of colorectal cancer.

Methods

74 cases of pathologically confirmed colorectal cancer with liver metastasis underwent resection from our hospital were included. Tissue microarrays were used for the interpretation of PD-L1 expression, cluster of differentiation 4 (CD4) and CD8 density by immunohistochemistry. We evaluated the disparity between primary tumor and liver metastasis

SUBMITTER: Wei XL 

PROVIDER: S-EPMC7730753 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature