Differential genetic mutations of ectoderm, mesoderm, and endoderm-derived tumors in TCGA database.

ABSTRACT:

Background

In terms of biological behavior, gene regulation, or signaling pathways, there is a certain similarity between tumorigenesis and embryonic development of humans. Three germ layer structure exhibits the distinct ability to form specific tissues and organs.

Methods

The present study set out to investigate the genetic mutation characteristics of germ layer differentiation-related genes using the tumor cases of the cancer genome atlas (TCGA) database.

Results

These tumor samples were divided into three groups, including the ectoderm, mesoderm, and endoderm. Children cases less than 9 years old accounted for a larger proportion for the cases in the ectoderm and mesoderm groups; whereas the middle-aged and elderly individuals (from 50 to 89 years old) were more s

SUBMITTER: Gao X 

PROVIDER: S-EPMC7730784 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature