Modulation of Brain Hyperexcitability: Potential New Therapeutic Approaches in Alzheimer's Disease.

ABSTRACT: People with Alzheimer's disease (AD) have significantly higher rates of subclinical and overt epileptiform activity. In animal models, oligomeric Aβ amyloid is able to induce neuronal hyperexcitability even in the early phases of the disease. Such aberrant activity subsequently leads to downstream accumulation of toxic proteins, and ultimately to further neurodegeneration and neuronal silencing mediated by concomitant tau accumulation. Several neurotransmitters participate in the initial hyperexcitable state, with increased synaptic glutamatergic tone and decreased GABAergic inhibition. These changes appear to activate excitotoxic pathways and, ultimately, cause reduced long-term potentiation, increased long-term depression, and increased GABAergic inhibitory remodelling at the network lev

SUBMITTER: Toniolo S 

PROVIDER: S-EPMC7730926 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature