Permeation of β-Lactamase Inhibitors through the General Porins of Gram-Negative Bacteria.

ABSTRACT: Modern medicine relies upon antibiotics, but we have arrived to the point where our inability to come up with new effective molecules against resistant pathogens, together with the declining private investment, is resulting in the number of untreatable infections increasing worldwide at worrying pace. Among other pathogens, widely recognized institutions have indicated Gram-negative bacteria as particularly challenging, due to the presence of the outer membrane. The very first step in the action of every antibiotic or adjuvant is the permeation through this membrane, with small hydrophilic drugs usually crossing through protein channels. Thus, a detailed understanding of their properties at a molecular level is crucial. By making use of Molecular Dynamics simulations, we compared the two m

SUBMITTER: Pira A 

PROVIDER: S-EPMC7730927 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature