Profiling the Murine SUMO Proteome in Response to Cardiac Ischemia and Reperfusion Injury.

ABSTRACT: SUMOylation is a reversible posttranslational modification pathway catalyzing the conjugation of small ubiquitin-related modifier (SUMO) proteins to lysine residues of distinct target proteins. SUMOylation modifies a wide variety of cellular regulators thereby affecting a multitude of key processes in a highly dynamic manner. The SUMOylation pathway displays a hallmark in cellular stress-adaption, such as heat or redox stress. It has been proposed that enhanced cellular SUMOylation protects the brain during ischemia, however, little is known about the specific regulation of the SUMO system and the potential target proteins during cardiac ischemia and reperfusion injury (I/R). By applying left anterior descending (LAD) coronary artery ligation and reperfusion in mice, we detect dynamic chan

SUBMITTER: Hotz PW 

PROVIDER: S-EPMC7731038 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature