Specificity of Interactions between Components of Two Zinc ABC Transporters in Paracoccus denitrificans.

ABSTRACT: Bacterial ATP binding cassette (ABC) transporters mediate the influx of numerous substrates. The cluster A-I ABC transporters are responsible for the specific uptake of the essential metals zinc, manganese or iron, making them necessary for survival in metal-limited environments, which for pathogens include the animal host. In Paracoccus denitrificans, there are two zinc ABC transporter systems: ZnuABC and AztABCD with apparently redundant functions under zinc-limited conditions. The unusual presence of two zinc ABC transporter systems in the same organism allowed for the investigation of specificity in the interaction between the solute binding protein (SBP) and its cognate permease. We also assessed the role of flexible loop features in the SBP in permease binding and zinc transpo

SUBMITTER: Melendez AB 

PROVIDER: S-EPMC7731109 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature