In Vitro Induction of Trained Innate Immunity by bIgG and Whey Protein Extracts.

ABSTRACT: Bovine immunoglobulin G (bIgG) was previously shown to enhance innate immune responses to toll-like receptor (TLR) stimulation, via induction of trained immunity. In this study, we investigated whether minimally processed dairy streams with high levels of whey proteins as potential infant nutrition ingredients could also induce trained immunity, and to what extent this can be explained by the presence of bIgG. The minimally processed whey ingredients serum protein concentrate (SPC) and whey protein concentrate (WPC) were tested for their ability to induce trained immunity in human peripheral blood monocytes. Both ingredients induced trained immunity as evidenced by an increased production of TNF-α and, to a lesser extent, of IL-6 upon stimulation with TLR ligands. This was comparable to is

SUBMITTER: Hellinga AH 

PROVIDER: S-EPMC7731221 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature