Determinants of Staphylococcus aureus carriage in the developing infant nasal microbiome.

ABSTRACT:

Background

Staphylococcus aureus is a leading cause of healthcare- and community-associated infections and can be difficult to treat due to antimicrobial resistance. About 30% of individuals carry S. aureus asymptomatically in their nares, a risk factor for later infection, and interactions with other species in the nasal microbiome likely modulate its carriage. It is thus important to identify ecological or functional genetic elements within the maternal or infant nasal microbiomes that influence S. aureus acquisition and retention in early life.

Results

We recruited 36 mother-infant pairs and profiled a subset of monthly longitudinal nasal samples from the first year after birth using shotgun metagenomic sequencing. The infant nasal microbiome is highly variable, particula

SUBMITTER: Accorsi EK 

PROVIDER: S-EPMC7731505 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature