Epigenome-wide association study identifies DNA methylation markers for asthma remission in whole blood and nasal epithelium.

ABSTRACT:

Background

Asthma is a chronic respiratory disease which is not curable, yet some patients experience spontaneous remission. We hypothesized that epigenetic mechanisms may be involved in asthma remission.

Methods

Clinical remission (ClinR) was defined as the absence of asthma symptoms and medication for at least 12 months, and complete remission (ComR) was defined as ClinR with normal lung function and absence of airway hyperresponsiveness. We analyzed differential DNA methylation of ClinR and ComR comparing to persistent asthma (PersA) in whole blood samples (n = 72) and nasal brushing samples (n = 97) in a longitudinal cohort of well characterized asthma patients. Significant findings of whole blood DNA methylation were tested for replication in two independent cohorts, Li

SUBMITTER: Qi C 

PROVIDER: S-EPMC7731549 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature