Vitamin D status is associated with hepcidin and hemoglobin concentrations in patients with severe traumatic injury.

ABSTRACT:

Background

Severe traumatic injury leads to persistent injury-associated anemia that is associated with hypercatecholaminemia, systemic inflammation, increased hepcidin, and a functional iron deficiency. Vitamin D has been shown to reduce proinflammatory cytokines and hepcidin concentrations. This study aimed to investigate the association of vitamin D status with inflammation, iron biomarkers, and anemia following blunt trauma.

Methods

A prospective observational cohort study comparing blunt trauma patients (n = 45) with elective hip replacement patients (n = 22) and healthy controls (n = 8) was performed. Bone marrow ferroportin, transferrin receptor, and erythroferrone expression was measured using quantitative polymerase chain reaction (qPCR). Plasma was assessed for sys

SUBMITTER: Apple CG 

PROVIDER: S-EPMC7731614 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature