Interleukin-33 gene polymorphisms and chronic obstructive pulmonary disease in the Chinese Han population.

ABSTRACT:

Objective

To investigate the relationship between interleukin (IL)-33 gene polymorphisms rs928413 and rs7044343 with chronic obstructive pulmonary disease (COPD) in the Chinese Han population.

Method

We assessed IL-33 rs928413 and rs7044343 polymorphisms by Sanger sequencing of PCR products amplified from the genomic DNA of 160 COPD patients and 123 healthy controls.

Results

There was no significant difference in the distribution of rs928413 AA, AG, or AA genotypes or rs7044343 CC, CT, or TT genotypes between the two groups. However, COPD patients had a significantly higher frequency of the rs928413 G allele G (14.1% vs 7.3%, respectively). This allele was significantly associated with susceptibility to COPD (odds ratio [OR]: 2.04, 95% confidence interval [CI]: 1.12-3

SUBMITTER: Xu X 

PROVIDER: S-EPMC7731714 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature